Here's our mini preview for the weekend's action, featuring the likes of Sheffield United's huge game against Manchester United, and Chelsea's big trip to the Etihad Stadium to take on Pep Guardiola's Manchester United.
1. Jose Mourinho set for first Spurs match
The Special One's first game as Spurs manager being the televised Saturday lunchtime match really is a treat. Will he turn the free-flowing side into a turgid defensive unit? Harry Kane will certainly hope not!
2. Arsenal could welcome back axed midfielder for Saints game
Granit Xhaka's last match in a Gunners shirt saw him booed off the field, and stripped of the captaincy. Unai Emery has hinted that he could play this weekend, in what should be an easy task for Arsenal.
3. Sheffield United boss to make last-minute call on John Egan
John Egan was injured on international duty in midweek, and Chris Wilder will make a late decision on whether to risk him against Manchester United. The Red Devils have won just once on the road in the league this season.
4. Quique Snchez Flores eager to shake up Hornets formation
Watford are hoping to follow up their win over Norwich with one against Burnley. Their manager has hit back at claims that he's a defensive coach, and hinted that he'll look to play a 4-4-2 once his side hit their stride.